Louis Rees-Zammit will start at full-back in Walesโ Autumn Nations Series clash with Argentina on Saturday.
He switches from the wing to fill a problem position for Wales, with Liam Williams and Leigh Halfpenny both injured.
Rees-Zammit made his Test debut after going on as a second-half substitute for Halfpenny against France in 2020, but the Gloucester speedsterโs subsequent 19 appearances were all on the wing.
Alex Cuthbert, who has recovered from injury, completes the back three alongside Rio Dyer, a try-scorer on his Test debut when New Zealand beat Wales 55-23 last weekend.
Gareth Anscombe, who deputised for Halfpenny five days ago, reverts to fly-half, replacing Rhys Priestland.
Elsewhere, prop Dillon Lewis starts instead of Tomas Francis and experienced Ospreys flanker Dan Lydiate features in the back-row.
With Leicester flanker Tommy Reffell sidelined because of a rib injury, captain Justin Tipuric moves across to openside, packing down with number eight Taulupe Faletau in a back-row trio boasting 246 caps.
There is no place in the matchday 23 for Walesโ record cap holder Alun Wyn Jones, as Ben Carter provides second-row cover, with other bench changes seeing props Rhodri Jones and Sam Wainwright selected, plus Priestland and Ospreys flanker Jac Morgan.
Wales head coach Wayne Pivac said: โLast week we had Leigh Halfpenny unavailable at the last minute and we had trained a certain way, so we went with Gareth Anscombe at full-back, who has done that before at this level.
โWe are back to Gareth at 10, and we have Louis Rees-Zammit at full-back. He (Rees-Zammit) has trained there the entire week.
โHe has looked good in training and it is something weโve explored in the background, so it will be good information going forwards with the Six Nations around the corner and the Rugby World Cup.
โDillon did well in South Africa. This is probably the last opportunity to give guys starts and learn as much as we can. Both Dillon and Dan Lydiate have trained well.
โThere are some changes among the replacements. There are some niggles that players pick up in games and in training, so some guys have been left out to get themselves 100 per cent right for next week.
โSome boys we want to have a look at across the competition, so in the case of Nicky Smith and Rhodri Jones that is certainly what we wanted to do in the first couple of games.โ
Argentina have arrived in Cardiff on the back of a 30-29 victory over England, which was their first win at Twickenham for 16 years.
Pivac added: โWe saw last week what Argentina are capable of. They are a very big team, very strong up front.
โThey have expanded their attacking game and they took an excellent try against England from set-play. Theyโve knocked over some big scalps in the last 18 months, New Zealand being one of them.
โThey are going to be a big challenge, but one we are looking forward to. After last weekโs performance we need a reaction from our team.โ
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